EFFECTS IN VITRO AND IN VIVO OF STII: A NATURAL COMPOUND WITH ANTITUMORAL PROPERTIES

• Carmen de los Ángeles Soto Febles

• English

• actinoporins
• cancer
• cell death
• pore forming toxins

SticholysinII (StII) is a protein purified from the sea anemone Stichodactyla helianthus. Based on its ability to form pores in membranes, we evaluated their effects in vitro and in vivo in tumor cells in order to study the antitumor properties of this toxin. In order to understand the cell pathways triggered upon membrane destabilization by StII, we have examined the mechanisms that mediate its cytotoxicity on tumor cells. StII's action on L1210, Raji, X63, B16, A549 tumor cells leads to an inc...