High-Throughput Screen to Identify LAPTc Inhibitors as in vitro Antichagasic Agents Using RapidFire Mass Spectrometry

• Lic. Mirtha Elisa Aguado Casas

• Póster digital
• English

• laptc inhibitor
• leucyl aminopeptidase
• rapidfire mass spectrometry assay
• trypanosoma cruzi

The American trypanosomiasis better known as Chagas disease is a systemic infection caused by the protozoan Trypanosoma cruzi. It is estimated 56,000 new cases and 12,000 deaths annually in the Americas region in 21 countries. The chemotherapy of the disease is still inadequate. Several proteases involving in vital processes for the survival of parasites such as invasion, migration, nutrition, immune response evasion and immunomodulation have been described. The presence of the leucyl aminopepti...