Virtual screening and synthesis of novel tetrazole-thiadiazine-2-thionas hybrids

• Javier Alfonso

• English

• molecular docking
• multicomponent reaction
• tetrazole
• thiadiazine
• trypanosoma cruzi
• trypanothione reductase

Chagas Disease is wide spread through the population in Latin American, affecting around 15 million of people. This illness has been regarded as neglected, since its prevalence is only significant in developing countries. Current therapies are inefficient and a plausible solution is only possible through academic research. The parasitic protozoa responsible for this disease is Trypanosoma cruzi. Trypanothione Reductase (TR) is the main detoxification enzyme of this parasite and it has been ident...