Studying intracellular signaling pathways by quantitative immunoelectron microscopy during chronic human diseases

• Dr. Nelson Acosta Rivero

• English

• diabetic foot ulcers
• egfr
• heberprot-p
• hepatitis c virus
• immunoelectron microscopy
• membrane contact sites

Most studies of signaling pathways analyze the levels of whole populations of modified/unmodified proteins in a group of cells. However, key signaling and cellular processes signal through different complexes and/or from various cellular compartments and differentially in individual cells. In addition, chronic diseases such as diabetic foot ulcers (DFUs) and hepatitis C virus (HCV) infection lead to cellular stress and extensive remodeling of intracellular membranes and organelles. To restore ho...