IN VITRO EVALUATION OF ARYLSUBSTITUTED IMIDAZOLES AS ANTIPROTOZOAL AGENTS AND DOCKING STUDIES ON STEROL 14α-DEMETHYLASE (CYP51) FROM T. CRUZI, L. INFANTUM AND T. BRUCEI.

• MsC. Julio Rojas Vargas

• English

• arylsusbtituted imidazoles
• in vitro evaluation
• leishmania infantum
• molecular docking
• trypanosoma b. rhodesiense
• trypanosoma brucei
• trypanosoma cruzi

There is an urgent need to discover and develop new drugs to combat parasitic diseases as Chagas disease (Trypanosoma cruzi), Sleeping sickness (Trypanosoma brucei) and Leishmaniasis (Leishmania ssp). These diseases are considered among the thirteen most unattended diseases worldwide according to the WHO. In the present work, the synthesis of 14 arylsubstituted imidazoles and its molecular docking onto sterol 14α-demethylase (CYP51) was executed. In addition, the compounds, antiprotozoal activit...