Trabajos

MOLECULAR DOCKING STUDY ON THE INTERACTION BETWEEN 2-SUBSTITUTED-4,5-DIFURYL IMIDAZOLES WITH DIFFERENT PROTEIN TARGET FOR ANTILEISHMANIAL ACTIVITY.

  • MsC. Julio Rojas Vargas

Leishmaniasis is a disease which is caused by the protozoa Leishmania and is considered the second-highest cause of death worldwide by parasitic infection. Looking for the right chemotherapy against leishmaniases has been difficult because of the high toxicity of the most effective drugs. Computational Chemistry plays an important role in the research of new possible medicines. In this work, docking analysis was carried out to study the effects of nine 4,5-di (furan-2-yl-1 H-imiazole) on Leishma...

Multicomponent preparation, characterization and in silico analysis of potential inhibitors of Pseudomonas aeruginosa quorum sensing receptor LasR

  • Mr. Marcos Rafael Conde González

Pseudomonas aeruginosa is a pathogenic Gram-negative bacterium responsible for several serious infections, being the main cause of pulmonary infections in patients with cystic fibrosis. The expression of the virulence and toxicity factors in the parasite is carried out by a mechanism known as quorum sensing, controlled by various transcription factors, among which is the protein LasR. Blocking this process contributes to prevent damages in animals from the pathogen. Therefore, the synthesis of m...

IDENTIFYING THE INTERACTIONS OF THREE IMMUNOSUPPRESSANTS WITH FKBP12 INTRAMOLECULAR RECEPTOR: A THEORETICAL STUDY

  • Sr. Anthuan Ferino Pérez

Understanding principles of molecular recognition is a challenging problem in contemporary molecular biology and theoretical biochemistry that could be approached with molecular modeling. Peptidyl-prolyl cis-trans isomerase FKBP1A (known as FKBP12) is a member of the immunophilin protein family, which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking and that binds the immunosuppressants rapamycin (sirolimus), everolimus and temsirolimus. An ...

MOLECULAR DOCKING STUDY ON THE INTERACTION BETWEEN 2-SUBSTITUTED-4,5-DIFURYL IMIDAZOLES WITH DIFFERENT PROTEIN TARGET FOR ANTILEISHMANIAL ACTIVITY.

  • MsC. Julio Rojas Vargas

Leishmaniasis is a disease which is caused by the protozoa Leishmania and is considered the second-highest cause of death worldwide by parasitic infection. Looking for the right chemotherapy against leishmaniases has been difficult because of the high toxicity of the most effective drugs. Computational Chemistry plays an important role in the research of new possible medicines. In this work, docking analysis was carried out to study the effects of nine 4,5-di (furan-2-yl-1 H-imiazole) on Leishma...

MOLECULAR DOCKING STUDIES OF ARYLSUBSTITUTED IMIDAZOLES AND THE ONCOGENIC PROTEIN BCR-ABL TYROSINE KINASE.

  • MsC. Julio Rojas Vargas

The treatment of chronic myeloid leukemia (CML) should be considered one of the medical successes of the last 30 years. CML is a myeloproliferative disorder that seriously compromises the health and lifestyle of the patient who suffers. If not detected in time, the evolution of it can lead to a fatal end. The Philadelphia Chromosome (CrPh) is present in approximately 95% of patients with CML, constituting a diagnostic marker of the disease. It is formed by the Bcr-Abl oncogene. In the present wo...

IN VITRO EVALUATION OF ARYLSUBSTITUTED IMIDAZOLES AS ANTIPROTOZOAL AGENTS AND DOCKING STUDIES ON STEROL 14α-DEMETHYLASE (CYP51) FROM T. CRUZI, L. INFANTUM AND T. BRUCEI.

  • MsC. Julio Rojas Vargas

There is an urgent need to discover and develop new drugs to combat parasitic diseases as Chagas disease (Trypanosoma cruzi), Sleeping sickness (Trypanosoma brucei) and Leishmaniasis (Leishmania ssp). These diseases are considered among the thirteen most unattended diseases worldwide according to the WHO. In the present work, the synthesis of 14 arylsubstituted imidazoles and its molecular docking onto sterol 14α-demethylase (CYP51) was executed. In addition, the compounds, antiprotozoal activit...

MOLECULAR DOCKING STUDIES OF ARYLSUBSTITUTED IMIDAZOLES AND THE ONCOGENIC PROTEIN BCR-ABL TYROSINE KINASE.

  • MsC. Julio Rojas Vargas

The treatment of chronic myeloid leukemia (CML) should be considered one of the medical successes of the last 30 years. CML is a myeloproliferative disorder that seriously compromises the health and lifestyle of the patient who suffers. If not detected in time, the evolution of it can lead to a fatal end. The Philadelphia Chromosome (CrPh) is present in approximately 95% of patients with CML, constituting a diagnostic marker of the disease. It is formed by the Bcr-Abl oncogene. In the present wo...

Virtual screening and synthesis of novel tetrazole-thiadiazine-2-thionas hybrids

  • Javier Alfonso

Chagas Disease is wide spread through the population in Latin American, affecting around 15 million of people. This illness has been regarded as neglected, since its prevalence is only significant in developing countries. Current therapies are inefficient and a plausible solution is only possible through academic research. The parasitic protozoa responsible for this disease is Trypanosoma cruzi. Trypanothione Reductase (TR) is the main detoxification enzyme of this parasite and it has been ident...

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