Trabajos

COMPARISON OF THREE ESCHERICHIA COLI STRAINS IN RECOMBINANT PRODUCTION OF HUMAN PAPILLOMAVIRUS 18 L1 PROTEIN

  • Dr. Elsa Pimienta

Human papillomavirus (HPV) has been implicated in 99.7% of cervical squamous cell cancer cases (CCU) worldwide. HPV16 and HPV18 are known to cause around 70% of CCU. In particular, the genotype 18 (HPV-18) is the second most prevalent worldwide and it has been included in the commercial preventive vaccines against HPV; which are based on the antigenicity of the major capsid protein L1. These vaccines are highly expensive and are unavailable for the most needed populations in developing countries...

OBTAINING L1 PROTEINS FROM HUMAN PAPILOMAVIRUS TYPES 16 AND 18 IN E. COLI® T7

  • MsC. Susana Brito Molina

The incidence of Cervical Cancer (CC) worldwide is 530,000 cases per year, of which 85% occur in developing countries. Genotypes 16 and 18 are identified as the most prevalent and responsible for 70% of cases of CC worldwide. The vaccines currently available against HPV are highly expensive, which limits their use in developing countries like our country. L1 is the major capsid protein of the HPV, it can be expressed recombinantly in strains of Escherichia coli. In our laboratory, the HPV 16 and...

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