Dealing with cyclization in the synthesis of spiroindol(en)ines and tetrazole-isoquinolones/pyridones hybrids

• MsC. Gerardo Ojeda

• English

• c-h activation
• catalysis
• cyclization
• heterocycle
• multicomponent
• spirocycle

Heterocyclic scaffolds are present in numerous bioactive compounds and natural products that exhibit a wide variety of pharmacological activities, thus the development of new synthetics strategies to obtain heterocycles is still a very active research area. The present work describes some of the most recent methods that have been developed in our lab for the synthesis of this very important class of compounds. First, we present two different approaches for the synthesis of spiroindol(en)ines. On...