7th International Symposium of Pharmaceutical Sciences "VII SICF" -7th Symposium "Design, Production and Development of Drugs"

7th International Symposium of Pharmaceutical Sciences

VII SICF

CHEMINFORMATICS MODELS BASED ON MACHINE LEARNING FOR THE IDENTIFICATION OF POTENTIAL LEISHMANIA INHIBITORS.

Abstract

Classified by the World Health Organization in category I of infectious diseases and part of neglected tropical pathologies leishmaniasis is defined as a set of diseases of very varied clinical presentation produced by obligate intracellular parasites belonging to the genus Leishmania.. Leishmania infantum specie mainly affects children under five years of age and has been associated with an increase in the appearance of cutaneous and visceral leishmaniasis. The search for new therapeutic alternatives remains a challenge and in silico studies are alternative tools to solve this problem. With the main objective of identify potentially effective compounds against Leishmania infantum through in silico studies, Artificial Intelligence Techniques implemented in the WEKA program and molecular descriptors 0D-2D of DRAGON software are used in this research. A new database was created and the clusters analysis (AC) k-means was used to design the training and prediction series. Four models were obtained with the following techniques: IBk, J48, MLP and SMO that reached percentages of classification higher than 80% for training and prediction series, whose predictive power was confirmed through external and internal validation procedures. The use of the models obtained in the virtual screening of the international database DrugBank and synthesis compounds allowed the optimal identification of 120 new potentially active compounds against Leishmania infantum amastigote form.

Resumen

Classified by the World Health Organization in category I of infectious diseases and part of neglected tropical pathologies leishmaniasis is defined as a set of diseases of very varied clinical presentation produced by obligate intracellular parasites belonging to the genus Leishmania.. Leishmania infantum specie mainly affects children under five years of age and has been associated with an increase in the appearance of cutaneous and visceral leishmaniasis. The search for new therapeutic alternatives remains a challenge and in silico studies are alternative tools to solve this problem. With the main objective of identify potentially effective compounds against Leishmania infantum through in silico studies, Artificial Intelligence Techniques implemented in the WEKA program and molecular descriptors 0D-2D of DRAGON software are used in this research. A new database was created and the clusters analysis (AC) k-means was used to design the training and prediction series. Four models were obtained with the following techniques: IBk, J48, MLP and SMO that reached percentages of classification higher than 80% for training and prediction series, whose predictive power was confirmed through external and internal validation procedures. The use of the models obtained in the virtual screening of the international database DrugBank and synthesis compounds allowed the optimal identification of 120 new potentially active compounds against Leishmania infantum amastigote form.

About The Speaker

Naivi Flores Balmaseda

Naivi Flores Balmaseda

UCLV Flag of Cuba
Practical Info
Póster digital
Spanish / Español
Not defined
5 minutes
Not defined
Authors
Juan alberto castillo garit.
Naivi Flores Balmaseda
Susanarojas socarrás
Keywords
amastigote
leishmania
machine learning
virtual screening