Synthesis and caracterization of Streptococcus Pneumoniae capsular polysacharide glycoconjugates obtained by oxidation with TEMPO/NaBr/NaClO

• Lic. Abel Zanuy

• English

• conjugated vaccine
• edc
• glycoconjugation
• s. pneumoniae
• tempo oxidation
• ugi 4c

Streptococcus pneumoniae is a Gram-positive bacterium responsible for multiple invasive and non-invasive diseases in humans. According to the World Health Organization this is one of the leading causes of death in children under 5 years. Carbohydrate-protein conjugate vaccines protect infants; since they induce a powerful immune response and generate immunological memory against the capsular polysaccharide of the bacteria. Union between polysaccharide and protein requires sufficient complementar...