IDENTIFICATION OF MULTI-TARGET COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE. MOLECULAR DYNAMICS STUDIES.

• MsC. Alberto Benomo Martínez

• English

• acetyl-cholinesterase
• alzheimer`s
• amyloid-beta
• γ-secretase

Alzheimer`s disease (AD) is an irreversible, neurodegenerative and multifactorial brain disorder that slowly destroys memory and thinking skills. Several target proteins contributing to its aetiology. Different targets of these disease include amyloid-beta peptide (Aβ), APP pathogenic cleavage, cholinergic system and neurotransmitter. Thus, disease-modifying treatments for AD must interfere with the pathogenic steps responsible for each of the clinical symptoms. In these work, we use docking and...