VII Simposio Internacional de Ciencias Farmacéuticas 2019 "VII SICF" -IV Simposio Internacional "Química de los productos naturales"

VII Simposio Internacional de Ciencias Farmacéuticas 2019

VII SICF

ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF EXTRACTS OF THE PLANT ADELIA RICINELLA L.

Resumen [ES]

Adelia ricinella L. is a Caribbean plant used as antipyretic, anti-inflammatory and analgesic, of which there is few phytochemical and pharmacological information to support its traditional uses. In this research the antioxidant and anti-inflammatory activities of three extracts (95% ethanol, 50% ethanol and water) obtained from aerial parts were evaluated using Soxhlet extraction. The main secondary metabolites were determined from qualitative and quantitative point of view. Antioxidant activity was measured using in-vitro radical scavenging methods facing ABTS and DPPH radicals. The anti-inflammatory activity was evaluated trough of acute inflammation model of paw edema induced by 1% Formalin in BAL/c mice, with indomethacin as positive control. The chemical qualitative analysis showed the presence of alkaloids, coumarins, reducing sugars, phenols, carbohydrates and flavonoides. The ethanol 50 % extract exhibited higher content of reducing sugars, phenols, carbohydrates and flavonoides. Like wise, ethanol 50 % extract was the most active with an average inhibitory concentration (IC50) of 0.29 ± 0.01 mg/mL and 0.53 ± 0.02 mg/mL against ABTS and DPPH respectively. In addition, the experimental group treated with 50% extract showed the highest percentage of inhibition of inflammation, being classified as a good anti-inflammatory with statistical difference with respect to the indomethacin control group (p <0.05). These results contribute to support the traditional use of this plant reported by Cuban population.

Resumen [EN]

Adelia ricinella L. is a Caribbean plant used as antipyretic, anti-inflammatory and analgesic, of which there is few phytochemical and pharmacological information to support its traditional uses. In this research the antioxidant and anti-inflammatory activities of three extracts (95% ethanol, 50% ethanol and water) obtained from aerial parts were evaluated using Soxhlet extraction. The main secondary metabolites were determined from qualitative and quantitative point of view. Antioxidant activity was measured using in-vitro radical scavenging methods facing ABTS and DPPH radicals. The anti-inflammatory activity was evaluated trough of acute inflammation model of paw edema induced by 1% Formalin in BAL/c mice, with indomethacin as positive control. The chemical qualitative analysis showed the presence of alkaloids, coumarins, reducing sugars, phenols, carbohydrates and flavonoides. The ethanol 50 % extract exhibited higher content of reducing sugars, phenols, carbohydrates and flavonoides. Like wise, ethanol 50 % extract was the most active with an average inhibitory concentration (IC50) of 0.29 ± 0.01 mg/mL and 0.53 ± 0.02 mg/mL against ABTS and DPPH respectively. In addition, the experimental group treated with 50% extract showed the highest percentage of inhibition of inflammation, being classified as a good anti-inflammatory with statistical difference with respect to the indomethacin control group (p <0.05). These results contribute to support the traditional use of this plant reported by Cuban population.

Sobre el ponente

Clara Azalea Berenguer Rivas

MsC. Clara Azalea Berenguer Rivas

Universidad de oriente Flag of Cuba
Información Práctica
No Presencial
English (US)
junio 26, 2019 2:0 p. m.
Restaurante "El Tesico"
Autores
Dr. edgar puente zapata
Msc. pedro l. batista corbal
MsC. Clara Azalea Berenguer Rivas
Dr.c julio césar escalona arranz
Lic. mariuska mas ortiz
Lic josué félix suárez cabrera.
Palabras clave
adelia ricinella l.
antioxidant activity and anti-inflammatory activity
chemical composition