VII Simposio Internacional de Ciencias Farmacéuticas 2019 "VII SICF" -IV Simposio Internacional "Química de los productos naturales"

VII Simposio Internacional de Ciencias Farmacéuticas 2019

VII SICF

ANTIPLATELET ACTIVITY OF CITRUS PLANT EXTRACTS

Resumen [ES]

The antithrombotic efficacy and safety of currently available antiplatelet drugs is limited for different reasons. Therefore, other effective, safe and low-cost therapeutic options are needed The fact that acetyl salicylic acid (ASA), a reference antithrombotic drug, was discovered from Salix alba L. (willow) allows suggesting that new therapeutic options could be developed from other plant species. Nevertheless, “antiplatelet” is not a popular term, being difficult to find clues from Ethnomedical studies. Instead, the knowledge of the antiplatelet activity of Citrus flavonoids suggesst that Citrus plants extracts could show this activity. The effect of Citrus aurantifolia Ch. (lime) leaves and Citrus sinensis L. (sweet orange) peels hydro-alcohol extracts, lime leaves extract (LLE) and sweet orange extract (SOPE) , respectively, on platelet aggregation (PA) were evaluated. LLE concentration dependently, inhibited PA in human platelet-rich plasma (PRP) in vitro induced by adenosine diphosphate (ADP) and epinephrine. On the other hand, SOPE prevented in vitro ADP-, collagen- and epinephrine-induced PA in a concentration dependent manner in human PRP, while ASA, was only effective against collagen and arachidonic acid . The ex vivo reduction of PA in rat PRP was demonstrated after a single intraperitoneal dose of SOPE. Like ASA, a seven-day treatment, but not a single oral dose of SOPE showed antiplatelet activity in rats. The results suggest that .C aurantifolia leaves and C. sinensis fruit peels could be the basis for the development of natural antiplatelet antiplatelet drugs.

Resumen [EN]

The antithrombotic efficacy and safety of currently available antiplatelet drugs is limited for different reasons. Therefore, other effective, safe and low-cost therapeutic options are needed The fact that acetyl salicylic acid (ASA), a reference antithrombotic drug, was discovered from Salix alba L. (willow) allows suggesting that new therapeutic options could be developed from other plant species. Nevertheless, “antiplatelet” is not a popular term, being difficult to find clues from Ethnomedical studies. Instead, the knowledge of the antiplatelet activity of Citrus flavonoids suggesst that Citrus plants extracts could show this activity. The effect of Citrus aurantifolia Ch. (lime) leaves and Citrus sinensis L. (sweet orange) peels hydro-alcohol extracts, lime leaves extract (LLE) and sweet orange extract (SOPE) , respectively, on platelet aggregation (PA) were evaluated. LLE concentration dependently, inhibited PA in human platelet-rich plasma (PRP) in vitro induced by adenosine diphosphate (ADP) and epinephrine. On the other hand, SOPE prevented in vitro ADP-, collagen- and epinephrine-induced PA in a concentration dependent manner in human PRP, while ASA, was only effective against collagen and arachidonic acid . The ex vivo reduction of PA in rat PRP was demonstrated after a single intraperitoneal dose of SOPE. Like ASA, a seven-day treatment, but not a single oral dose of SOPE showed antiplatelet activity in rats. The results suggest that .C aurantifolia leaves and C. sinensis fruit peels could be the basis for the development of natural antiplatelet antiplatelet drugs.

Sobre el ponente

Milagros T Garcia Mesa

Ph. D. Milagros T Garcia Mesa

Universidad de Ciencias Médicas de La Habana Flag of Cuba
Información Práctica
No Presencial
English (US)
junio 26, 2019 2:0 p. m.
Restaurante "El Tesico"
Autores
Ph. D. Milagros T Garcia Mesa
María A. Alfonso Valiente
Dulce M. Armenteros Herrera
Palabras clave
acetyl salicylic acid
citrus aurantifolia
citrus sinensis
platelet aggregation