VII Simposio Internacional de Ciencias Farmacéuticas 2019 "VII SICF" -IV Simposio Internacional "Química de los productos naturales"

VII Simposio Internacional de Ciencias Farmacéuticas 2019

VII SICF

Cytoprotective effect and phenolic composition of the aqueous extract from Halimeda opuntia seaweed.

Resumen [ES]

In recent years the pharmaceutical industry has strengthened the search for new drugs from natural products. In this context, marine algae have been an important source for the extraction of compounds with diverse biological activity. The seaweed Halimeda opuntia has antioxidant properties associated with the inhibition of lipid peroxidation; however, its possible cytoprotective effect against oxidative stress induced has not been studied. Therefore, the objective of this work is to evaluate the antioxidant and cytoprotective properties of the aqueous seaweed extract Halimeda opuntia in sheep erythrocytes and the H-125 cell line, as well as the relationship of such properties with the chemical composition and polyphenol content totals. The aqueous extract was able to inhibit AAPH-induced hemolysis in sheep erythrocytes with a dose-dependent response at concentrations between 12.5 and 100 mg / mL. The protection to H-125 cells line against H2O2-induced damage was demonstrated, dose-dependent concentrations between 200 and 800 µg / mL. In addition, the extract has reducing power, properties that are associated with the presence in this seaweed of 3 coumarins, and 3 phenolic acids, which justifies the antioxidant activity reported in this work.

Resumen [EN]

In recent years the pharmaceutical industry has strengthened the search for new drugs from natural products. In this context, marine algae have been an important source for the extraction of compounds with diverse biological activity. The seaweed Halimeda opuntia has antioxidant properties associated with the inhibition of lipid peroxidation; however, its possible cytoprotective effect against oxidative stress induced has not been studied. Therefore, the objective of this work is to evaluate the antioxidant and cytoprotective properties of the aqueous seaweed extract Halimeda opuntia in sheep erythrocytes and the H-125 cell line, as well as the relationship of such properties with the chemical composition and polyphenol content totals. The aqueous extract was able to inhibit AAPH-induced hemolysis in sheep erythrocytes with a dose-dependent response at concentrations between 12.5 and 100 mg / mL. The protection to H-125 cells line against H2O2-induced damage was demonstrated, dose-dependent concentrations between 200 and 800 µg / mL. In addition, the extract has reducing power, properties that are associated with the presence in this seaweed of 3 coumarins, and 3 phenolic acids, which justifies the antioxidant activity reported in this work.

Sobre el ponente

Daylín Díaz Gutierrez

MsC. Daylín Díaz Gutierrez

Facultad de Biología, Universidad de la Habana Flag of Cuba
Información Práctica
Póster digital
Spanish / Español
junio 26, 2019 2:0 p. m.
5 minutos
Restaurante "El Tesico"
Autores
Alina Forrellat
Trina García
Alexis Vidal
Jessica Gómez Lemus
MsC. Daylín Díaz Gutierrez
Iraida Spengler
Palabras clave
cytoprotective effect
halimeda opuntia
phenolic composition