VII Simposio Internacional de Ciencias Farmacéuticas 2019 "VII SICF" -VII Simposio "Diseño, Obtención y Desarrollo de Fármacos"

VII Simposio Internacional de Ciencias Farmacéuticas 2019

VII SICF

ZnO AND IRON OXIDES NANOPARTICLES WITH POTENTIAL APPLICATIONS IN BIOMEDICINE

Resumen [ES]

ZnO and iron oxide (ZnONPs and IONPs) received a great attention due to the possibility to be used in several areas of chemistry, physics and material science. The study related with nanoparticle−biological system interactions has increased in the past decade. For biomedical applications, a protective layer is formed on the surface of the particles via specific interactions or chemical bonding between the active sites of NPs and the coating molecules. The surface coating determines the properties of synthesized nanoparticles such as stability, solubility and their uses. ZnONPs and IONPs nanoparticles were made by precipitation and coprecipitation methods, respectively. β-CD, PEG diacid, silicate, 3-aminopropyltriethoxysilane (APTES) and tris(hydroxymethyl)aminomethane (TRIS) were used as coating agents of magnetite nanoparticles (IONPs). The synthesized ZnONPs and IONPs were characterized by IR spectroscopy, XRD, SEM and TEM. Zn-O (435 cm-1) and Fe-O (575 cm-1) stretching were observed in isolated nanoparticles. XRD measurements suggest the presence of wurtzite (ZnO) and magnetite (Fe3O4) phases. A spherical morphology was detected through SEM for IONPs, with an average particle size under 13 nm. On the other hand, nanodisc with approximately 25 nm length and 35 nm in diameter are observed in TEM micrographies for ZnONP. Magnetic separation assays of oligodeoxynucleotides (ODN) and plasmid DNA (pDNA) were carried out with IONPs.

Resumen [EN]

ZnO and iron oxide (ZnONPs and IONPs) received a great attention due to the possibility to be used in several areas of chemistry, physics and material science. The study related with nanoparticle−biological system interactions has increased in the past decade. For biomedical applications, a protective layer is formed on the surface of the particles via specific interactions or chemical bonding between the active sites of NPs and the coating molecules. The surface coating determines the properties of synthesized nanoparticles such as stability, solubility and their uses. ZnONPs and IONPs nanoparticles were made by precipitation and coprecipitation methods, respectively. β-CD, PEG diacid, silicate, 3-aminopropyltriethoxysilane (APTES) and tris(hydroxymethyl)aminomethane (TRIS) were used as coating agents of magnetite nanoparticles (IONPs). The synthesized ZnONPs and IONPs were characterized by IR spectroscopy, XRD, SEM and TEM. Zn-O (435 cm-1) and Fe-O (575 cm-1) stretching were observed in isolated nanoparticles. XRD measurements suggest the presence of wurtzite (ZnO) and magnetite (Fe3O4) phases. A spherical morphology was detected through SEM for IONPs, with an average particle size under 13 nm. On the other hand, nanodisc with approximately 25 nm length and 35 nm in diameter are observed in TEM micrographies for ZnONP. Magnetic separation assays of oligodeoxynucleotides (ODN) and plasmid DNA (pDNA) were carried out with IONPs.

Sobre el ponente

Alicia M. Díaz García

Prof. Alicia M. Díaz García

Universidad de La Habana Flag of Cuba
Información Práctica
English (US)
No definido
30 minutos
No definido
Autores
Alvaro lagar sosa
Greter Ortega Rodríguez
José raúl sosa acosta
Marquiza Sablón Carrasana
Mayreli Ortiz Rodríguez
Chryslaine Rodríguez Tanty
Julio César Zuaznabar Gardona
Fernando Bordallo León
Mayra p. hernández sánchez
Sergio Díaz Castañón
Prof. Alicia M. Díaz García
Palabras clave
iron oxide nanoparticles
magnetic separation
zno nanoparticles