Calcium phosphate bioceramics have been widely used in medical applications, such as orthopedics and odontology, due to the similarities of the synthesized material with the calcium phosphates present in the body. The chemical and mechanical properties of calcium phosphates can be adjusted according to the synthesis method and these materials will have different properties that allow them to be used in the preparation of durable implants or resorbable biomaterials. The objective of this work was to evaluate the solubility of calcium and phosphate ions in samples with different composition of ACP, HA and OCP phases synthesized by a wet reaction. The calcium phosphates were evaluated by X-ray diffraction (XRD), infrared Fourier transform (FT-IR), scanning electron microscopy (SEM), electron microscopy (TEM). The calcium and phosphate profile release from each formulation were similar. It was observed a decrease in these ions concentration in the first two days, followed by an increase in its concentration, whose equilibrium was reached after 7 days. The dissociation and reabsorption rate of these ions is a crucial point to understand the solubility of calcium phosphates e how the phase transformation act in bone regeneration.