In the context of economic globalization and the Fourth Industrial Revolution, efficient supply chain management has become a critical factor for competitiveness. In Cuba, where supply chains face significant technological and operational constraints, optimizing the information flow has acquired strategic importance, particularly following the country's accession to BRICS, which opens new avenues for technological transfer and logistical modernization. This study aimed to analyze, classify, and critically evaluate the models, technologies, and approaches of Logistics 4.0 applicable to information flow within supply chains, with the purpose of proposing an adaptable framework for the Cuban context. Through a systematic literature review and a comparative analysis of recent research published in indexed scientific journals, a qualitative approach was employed to synthesize findings and formulate strategic recommendations. The results identified key technologies—namely the Internet of Things (IoT), artificial intelligence (AI), and digital twins—as well as vertical and horizontal collaboration models that fundamentally transform information flow. The analysis revealed that, in resource-constrained environments, the most viable and scalable strategy involves the implementation of basic ERP and IoT systems combined with vertical collaboration models, thereby enabling process digitization, information standardization, and enhanced decision-making. It is concluded that Logistics 4.0 represents a continuous process of information flow transformation, whose successful adoption in Cuba will depend on an incremental strategy, coherent public policies, sustained investment in human capital, and the overcoming of cultural and organizational barriers.