The prospects for the use of supplementary cement materials depend to a large extent on their potential and their availability. In this work, the potentialities of three materials (calcined clays, zeolitized tuffs, vitreous tuffs) as sources of supplementary cementitious materials are presented. Each material was characterized from the chemical and mineralogical point of view. The reactivity was determined in standardized mortars and their behavior was assessed in mixed cements and hollow concrete blocks. Based on the results obtained, a comparison between the performances was made. The best results were shown by the calcined clay, followed by the zeolitized tuff and vitreous tuff, which corresponds to the reactivity of each material.