Numerous studies demonstrate that active phyto compounds as the saponin, contributes to improve the molecular processes associated to the obesity. The extracted saponin of the species Agave brittoniana T spp Brachypus has demonstrated to have potential antiobesity, however the effect of these is not known in healthy animals. He/she was carried out a pharmacological experimental study using rats healthy Wistar to evaluate the effect of the species it has more than enough parameters lipídicos, hepatic and renal. The doses of 400mg/kg of hydroalcoholic extract and 100mg/kg of their fraction butanolic were administered during 14 days. The lipidic profilewas evaluated determining cholesterol, TAG and VLDL and the transaminases and plasmatic albumin were quantified to evaluate hepatic and renal lesion, respectively. The rehearsal threw an effect reducer of significant triacylglyceride in the two groups of healthy animals that were administered the two products of the plant. Also, in this study the evaluated biochemical markers showed absence of hepatic and renal lesion for the administration of the products. You conclude that so much the extract hydroalcoholic of the species like their fraction butanolic diminish the triacylglyceride values in healthy animals without appreciating hepatic and renal toxicity to the rehearsal doses.