Drug repositioning for novel antitrichomonas from known antiprotozoan drugs using hierarchical screening

• Dr. Alfredo Meneses Marcel

• Póster digital
• Spanish / Español

• in vitro
• in vivo
• qsar
• trichomonas vaginalis

Metronidazole is the most widely used drug in trichomoniasis therapy. However, the emergence of metronidazole-resistant Trichomonas vaginalis isolates calls for the search for new drugs to counter the pathogenicity of these parasites. Classifiation models for predicting the antitrichomonas activity of molecules were built. These models were employed to screen antiprotozoal drugs, from which 20 were classifid as active. The in vitro experiments showed moderate to high activity for 19 of the molec...