Fixed oils of the Amazonian plants: Oenocarpus bataua Mart, Mauritia flexuosa L.f. and Fevillea cordifolia L. have polyunsaturated fatty acids with protective effects on the skin. The essential oils of Ocotea quixos (Lam.) Kosterm., Cymbopogon citratus (DC.) Stapf. and Zingiber officinale Roscoe, are composed of terpenoids with antioxidant and antimicrobial activity, and can be incorporated into cosmetic formulations. The objective was to develop a cosmetic cream with fixed and essential oils extracted from plants that grow in the Ecuadorian Amazon.Twenty formulations were elaborated based on an experimental design, considering different proportions of: montanov68, montanov202, cocoa butter, olive oil and sterile purified water to select one with ideal characteristics for a facial application, the response variables were: extensibility, viscosity, washability, and pH. Then, 14 formulations were elaborated according to the statistical design of mixtures (Design Expert) to incorporate the oily Amazonian raw materials and the one with the most suitable characteristics was selected, which was subjected to sensory tests. The best formulation was the one named in the work as number 7, which contained appropriate amounts of: cocoa butter, Oenocarpus bataua and Mauritia flexuosa oil in equal parts, mixture of the three essential oils (0.3 g in total), water purified and montanov202 plus montanov68. The pH of the formulation was 6.53, viscosity 4288.30 mPa.s, and extensibility 7 cm. The developed cosmetic cream had appropriate technological quality characteristics and can generate a new market for agro-industrial products that benefit the producing communities of the Ecuadorian Amazon Region.