VIII International Symposium on Chemistry and Pharmaceutical Sciences

SICF

VIII Symposium "Design, Obtaining and Development of Drugs"

Monday 13

November 2023

7 tracks

	Sala A SIQF	Sala B SIQF
	CONFERENCIA MAGISTRAL Comité Científico SIQF	BioCubaFarma, science and applied innovation with impacts on health and food Dr.C. Isis Belkis Yera Alós


4:00 PM
	PONENCIAS ORALES Comité Científico SIQF	Innovative topical bifunctional nano-hydrogel for the treatment of childhood atopic dermatitis María Javiera Alvarez Figueroa atopic dermatitis dermatitis atópica nanosistema nanosystem penetración trasndérmica transdermal delivery	DESIGN AND OPTIMIZATION OF MULTIFUNCTIONAL NANOSYSTEMS FOR NEEDLE-FREE VACCINATION José Vicente González libre de agujas nanotechnology nanotecnología needle-free vaccines vacunas
	Formulation of an emulgel from the leaves of Jatropha gossypifolia L., for the acne management. Mirtha Mayra González Bedia aacne acné diseño factorial emulgel factorial design formulación. formulation jatropha gossypifolia l.
	Acceptability and tolerability of hand sanitizers marketed during Covid 19 in four municipalities of Villa Clara. Mirtha Mayra González Bedia acceptability aceptabilidad desinfectantes de manos hand sanitizers protocolo-oms tolerabilidad tolerability who-protocol
5:00 PM

Tuesday 14

November 2023

75 tracks

	Sala Polivalente A	Sala A SIQF	Sala B SIQF
			Conferencia Magistral Comité Científico SIQF	Chemistry in vaccine development: experiences from the Finlay Vaccine Institute Yury Valdés Balbín

9:00 AM	Desarrollo y evaluación clínica de Quimi-Vio, vacuna cubana contra los neumoccocos Dagmar García Rivero


	Poencias Orales Comité Científico SIQF
10:00 AM	Chemically assisted dimerization of a recombinant RBD of SARS-CoV2 spike protein as an alternative source of antigen for Soberana 01 and Plus vaccines Jean Pierre Soubal disulfide bridge puente disulfuro rbd sars-cov-2 sars-cov2 soberana vaccine vacuna	Characterization of capsular polysaccharide and intermediated product of Cuban candidates’ vaccines against pneumococcal bacteria by HPSEC-MALS and DLS assay. Jessy Pedroso Fernández conjugate vaccine molecular weight neumoccoco particle size peso molecular pneumococcus potencial zeta tamaño de partícula vacuna conjugada zeta potential
	Characterization by Light Scattering techniques of the monovalent conjugate and intermediates of Soberana 02 vaccine. Raine Garrido Arteaga analysis análisis dispersión de la luz light scattering rbd sars-cov-2 vaccine vacuna
	Gadolinium(III) based contrast agents with potential applications in the early detection of Alzheimer's disease Gabriel Rafael Guerrero Porras alzheimer’s disease; mri contrast agent; gadolinium(iii) oxide nanoparticles; dota; amylovis® enfermedad de alzheimer; agentes de contrastes para rmi; nanopartículas de óxido de gadolinio(iii); dota; amylovis®	Characterization by LC-MS/MS of SOBERANA®02 Olivia Martínez Armenteros conjugate vaccine covid-19 cross-linked peptides péptido crosslinkeado rbd tetanus toxoid toxoide tetánico vacuna conjugada
		Ronda de preguntas Comité Científico SIQF
11:00 AM	DRUGS RELATED PROBLEMS IN ONCOLOGY PATIENTS SERVED AT THE HOSPITAL “DR. CELESTINO HERNANDEZ ROBAU” Yosvani Rodriguez cancer patient medication-related problems paciente oncológico problemas relacionados con la medicación	RECESO Dra. c. leisy nieto reyes
	Pharmacoeconomic analysis in the treatment of severe malaria in the Municipal Hospital of Malanje, Angola Dany Siverio Mota estudio farmacoeconómico. costo-efectividad. tratamiento del paludismo grave. artemeter. artesonato. pharmacoeconomic study. efectivity cost. treatment of severe malaria. artemether. coffered ceiling.
	IT IS POSSIBLE TO DESING AN EFFECTIVE ENVIRONMENTAL TRAINING STRATEGU FOR THE PHARMACEUTICAL PROFFESIONAL? Daymí Isabel Carrazana García análisis de riesgo y gestión de residuos de medicamentos curricular and extracurricular training formación curricular y extracurricular risk analysis and drug residue management.	Perspectives of nanomedicines in chronic and degenerative diseases Rosa Alondra Yazmin Ramírez Gutiérrez cancer cell regeneration micelas micelles nanoparticles nanopartículas polimeros polymers receptors regeneración celular
		Adherence to treatment in hypertensive patients in area 1 of Cienfuegos Dr.C. Leisy Nieto Reyes adherence to treatment adherencia al tratamiento antihypertensive treatment arterial hypertension enalapril hipertensión arterial morisky-green test test morisky-green tratamiento antihipertensivo
12:00 PM		Ronda de preguntas Comité Científico SIQF

	A cell-based ELISA as surrogate of virus neutralization assay for RBD SARS-CoV-2 specific antibodies. Franciscary Pi Estopiñan cell-based elisa cvnt elisa basado en células mvnt and vaccine mvnt y vacuna sars-cov-2	PONENCIAS VIRTUALES Dra. c. leisy nieto reyes
	Effectiveness of CIMAvax-EGF vaccine administered in the primary care setting: a real-world scenario clinical trial. Geidy Lorenzo Monteagudo atención primaria de salud cimavax-egf vaccine clinical trials ensayos clínicos primary health care vacuna cimavax-egf	PONENCIAS VIRTUALES Dra. c. leisy nieto reyes
1:00 PM	Physicochemical Characterization of a new anti-PD1 Monoclonal Antibody biosimilar candidate of nivolumab obtained in CHO-K1 cell line. Roberto Machado Santisteban anticuerpo monoclonal biosimilar caracterización characterization monoclonal antibody	Preliminary study for the development of a formulation of Lisinopril – Hydrochlorothiazide 20/25 mg Jorge Luis Castaño Fernández antihipertensivo antihypertensive hidroclorotiazida hydrochlorothiazide lisinopril tabletas tablets
	RESUMEN DE LA COMISION Dra. c. leisy nieto reyes	Study of thermal stress of the RBD molecules José Luis Duran Garcia estrés térmico rbd thermal stress vaccine vacuna

	PÓSTERS DIGITALES Comité Científico SIQF
2:00 PM



3:00 PM



4:00 PM	Study of reaction conditions to established a conjugation procedure of capsular polysaccharide Streptococcus pneumoniae serotype 22F Jean Pierre Soubal conjugate vaccine fragmentación de polisacárido polysaccharide fragmentation serotipo 22f serotype 22f streptococcus peumoniae streptococcus pneumoniae vacuna conjugada	Adsorption study for the formulations of the Soberana 01, 02 and Plus vaccines Lisandra Pérez Pérez adjuvancy adsorption percentage adyuvación aluminum salts mathematical mode modelo matemático porcentaje de adsorción sales de aluminio



5:00 PM	Gel-clot method as an alternative for the determination of bacterial endotoxins. An study case. Alina Cruz Ferrer bacterial endotoxins; gel-clot method endotoxinas bacterianas; método gelificación	Itolizumab in the treatment of moderate and severe patients with SARS-CoV-2 pneumonia Ana Rosa Valls Hung covid19 pneumonia itolizumab neumonía por covid19 sars-cov-2 virus virus sars-cov-2	Stability study of the IL2 non-alpha mutein under physicochemical stress conditions. Beatriz María Cruz Yero estabilidad estrés il-2 non-alpha mutein muteína il2 no alfa stability stress
	Quality attributes and stability of mAb P3Q, capture antigen of mAb racotumomab Gleydis Ojeda Varela acm; p3q; racotumomab; reconocimiento antigénico mab; p3q; racotumomab; antigen recognition	Standardization of a procedure based on the Purpald method for the determination of the activation levels of the Streptococcus pneumoniae serotype 5 polysaccharide. Felix Cardoso San Jorge espectrofotométrico purpald spectrophotometric streptococcus pneumoniae validación validation	Characterization of the RBD-hFc fusion protein used in diagnostics for COVID-19 UMELISA SARS-CoV-2-IgG Ingrid Ruiz analytical techniques caracterización characterization fusion protein protein proteína proteína de fusión rbd-hfc técnicas analíticas	Methodology for quality costs estimation and cost control during R & D stage in quality assurance Hainer Martínez Cabrera appraisal costs costos de calidad costos de evaluación costos de fallas costos de prevención failure costs prevention costs quality costs	IDENTIFICATION OF A CRITICAL QUALITY ATTRIBUTE FOR THE ACTIVE PHARMACEUTICAL INGREDIENT OF NEUROEPOplus Jani Laffitte García actividad neuroprotectora atributo crítico de calidad. critical quality attribute. isoform profile neuroepoplus neuroprotective activity perfil de isoformas	PEGylation strategy for improving the antitumoral activity of the IL-2 mutant no alpha. Marianniz Díaz Hernández actividad antitumoral antitumor activity interleucina 2 (il-2) interleukin 2 (il-2) pegilación pegylation polietilenglicol (peg) polyethylene glycol (peg)	PEGylation strategy for improving the pharmacokinetic activity of the IL-2 no-alpha mutein. Marianniz Díaz Hernández actividad antitumoral. antitumor activity. farmacocinética interleukin-2 (il-2) mutant mutante de interleucina-2 (il-2) pegilación pegylation pharmacokinetic	DEVELOPMENT OF AN IN VITRO BIOASSAY FOR HUMAN ERYTHROPOIETIN WITH A LOW CONTENT IN SIALIC ACID (NEUROEPOplus) BASED ON PROLIFERATIVE STIMULATION OF AN ERYTHROID CELL LINE Wilden Diaz González apoptosis epor inhibición inhibition neuroepoplus potencia potency proliferación proliferation tf1	DEVELOPMENT AND VALIDATION OF AN IN VITRO BIOASSAY TO EVALUATE THE POTENCY OF ITOLIZUMAB MAB IN HEK-293/CD6 CELL LINE BY FLOW CYTOMETRY Wilden Diaz González cd6 molecule citometría de flujo flow cytometry itolizumab molécula cd6 potencia potency validación validation	Capillary zone electrophoresis as bioactivity predictor of recombinant human Erythropoietin Danais Vidal Rossell eritropoyetina; bioactividad; electroforesis capilar de zona; i-number erythropoietin; bioactivity; capillary zone electrophoresis; i-number ibio-number	Validation of the bioburden assay for Montanode ISA 51 VG using the membrane filtration method. Yudith Ledo Ginarte bioburden; membrane filtration; montanide isavg51; analytical validation biocarga; filtración por membrana; montanide isa 51 vg; validación analítica	Validation of the IL-2 non-alpha mutein biological activity assay Gabriela Rivas García actividad biológica in vitro ctll-2 proliferation in vitro biological activity muteína il-2 no alfa non-alpha il-2 mutein potency assay validation proliferación de ctll-2 validación de ensayo de potencia	Analytical comparability of human serum albumin as an excipient produced by different suppliers Oscar Nicolás albumin albúmina biologicals biológicos comparabilidad comparability eritropoyetina erythropoietin proceso process regulatorio regulatory	REPEATED-DOSE TOXICITY AND IMMUNOGENICITY OF VACCINE CANDIDATES AGAINST SARS-COV-2 IN CERCOPITHECUS AETHIOPS Axel Mancebo immunogenicity inmunogenicidad non human primates primates no humanos repeated dose toxicity sars-cov-2 toxicidad a dosis repetida vaccines vacunas	Technological Development of an Oral Emulsion of Pumpkin Seed Lipid Extract (Cucurbita pepo L.) Nilia de la Paz Martin-Viaña Tecnología calabaza cucurbita pepo emulsion emulsión prostate próstata pumpkin reología rheology technology	Microencapsulation of Peppermint L. Essential Oil. Antonio Nogueira Mendoza Pharmaceutical Food Industry Tecnología aceite esencial encapsulasión encapsulation essential oil industria farmacéutica alimentaria technology	VALIDATION OF ANALYTIC METHODS FOR THE QUANTIFICATION DE BACLOFEN AND BUPIVACAINE BY CLAR Dr.C. Caridad Garcia Peña baclofen baclofeno bupivacaina bupivacaine estudios de estabilidad stability studies validación validation	Physicochemical characterization of CdTe/ZnS/MPA and CdTe/CdS/GSH quantum dots as specific biological markers Gabriela Travieso Aguilar fotoluminiscencia nanaomateriales nanomaterials photoluminescence puntos cuánticos quantum dots semiconductores semiconductors	Ubiquicidin 29-41 fragment labeled with 99mTc as a radiopharmaceutical for the study of infections. Javier Rodríguez Prats 99mtc [99mtc]tc-ubiquicidin [99mtc]tc-ubiquicidina antimicrobian peptide infección infection péptido antimicrobiano	Characterization of the physicochemical properties of the monoclonal antibody nimotuzumab in high concentration by dynamic light scattering. Yaiko Saddan Hernández Terrero aggregation agregación antibody anticuerpo dispersión de luz dinámica dynamic light scattering estabilidad formulaciones formulations nimotuzumab stability	Hydroxyapatite Nanoparticles as a Potential Long-Term Treatment of Cancer of Epithelial Origin Fernando Bordallo adjuvants adyuvantes anti-rhegf humoral response cancer treatment cimavax-egf immunotherapy inmunoterapía respuesta anti-rhegf humoral rhegf tratamiento del cáncer	Process design of production of capsules with 131I Alian Gil Acosta capsules cápsulas flow flujo manufacturing producción radiofármaco radiopharmceutical sodium iodide (131i) yoduro de sodio (131i)	Influence of Humoral Response against GnRH, Generated by Immunization with a Therapeutic Vaccine Candidate on the Evolution of Patients with Castration-Sensitive Prostate Adenocarcinoma. Ana Campal anticuerpos gnrh cancer de próstata gnrh antibody prostate cancer therapeutic vaccine vacuna terapeutica	Novel nanosystems based on magnetic nanoparticles as contrast agents in the early detection of Alzheimer´s disease Claudia González Castro agentes de contraste alzheimer´s disease contrast agents enfermedad de alzheimer ionps irm magnetic nanoparticles mri nanopartículas magnéticas	EXPERIMENTAL BIOMODEL OF METABOLIC SYNDROME. USEFULNESS IN THE SEARCH FOR PRODUCTS WITH AN ANTI-OBESITY EFFECT Yisel González Madariaga biomodelos experimentales experimental biomodels homa-fcβ homa-ri insulinemia metabolic syndrome metformin metformina síndrome metabólico	BIOMARKERS OF ENZYME ACTIVITY IN PATIENTS WITH EPITHELIAL TUMORS: METALLO-OXIDOREDUCTASE ENZYMES Lidia González Méndez , enzymatic methods biomarcador biomarkers enzimas metalo-óxidorreductasas epithelial tumors estrés oxidativo methal-oxidoreductase enzymes métodos enzimáticos oxidative stress tumores epiteliales	PERSISTENCE TO THE TREATMENT WITH BIPHOSPHONATES IN PATIENTS WITH POSTMENOPAUSAL OSTEOPOROSIS ATTENDED IN THE HOSPITAL “ARNALDO MILIÁN CASTRO” Lisbet Ojeda Juvier bifosfonatos bisphosphonates osteoporosis postmenopáusica persistence persistencia postmenopausal osteoporosis	Protective effects of Surfacen® in allergen-induced asthma mice model Odalys Blanco acaro del polvo domestico allergy animal mode asma asthma house dust mite modelo animal de alergia pulmonary surfactant surfactante pulmonar	“KNOWLEDGE ABOUT MEDICATION IN OLDER ADULTS. EDUCATIONAL PROPOSAL". Mileidys López Bacallao anciano educational proposal elderly medicación medication propuesta educativa
	“PROPOSAL FOR ACTIONS TO REDUCE THE CONSUMPTION OF PSYCHODRUGS IN OLDER ADULTS IN THE MEDICAL OFFICE N° 21 OF RODRIGO.” Mileidys López Bacallao acciones actions ancianos elderly psicofármacos psychodrugs	Computational identification of natural flavonoids as Polo-Like Kinase-1 inhibitors to slow cancer progression Dina Bárbara Aguado Herrera análisis discriminante lineal (adl) cancer cáncer flavonoides flavonoids linear discriminant analysis (lda) polo-like kinasa-1 (plk-1) polo-like kinase-1 (plk-1) quantitative structure-activity relationship (qsar). relación cuantitativa estructura-actividad (qsar).	CONSUMPTION OF PARENTERAL ANTIBIOTICS WITH ENVIRONMENTAL RISK Ivanie Herrera Milian consumo hospitalario; antimicrobianos; estudio de utilización de medicamentos; antibioresistencia bacteriana. hospital consumption; antimicrobials; drugs’ use study; antibiotic resistance	SCALING OF THE PROCESS OF OBTAINING THE SOFT EXTRACT OF PROPOLIS MSc. Ester María Hernández Martínez escalado extracto blando de propóleos proceso productivo production process propolis propolis soft extract propóleos scaling	IN VITRO ACTIVITY OF PBCA MESHES WITH DIFFERENT CONCENTRATIONS OF FURVINA Ester María Hernández Martínez actividad in vitro furvina in vitro activity mallas meshes nanoestructuras poliméricas pbca polymeric nanostructures	Validation of the determination of the dissolution test in batches of Vitrofural®, by UV/Vis spectrophotometry. Diana Leydis García Treto espectrofotometría uv/vis uv/vis spectrophotometry validación. validation. vitrofural®	DESIGN OF THE MEASUREMENT MANAGEMENT SYSTEM FOR THE CBQ MANUFACTURING PROCESSES Rosayda Baez Montesino calidad design diseño industria farmacéutica management system metrology metrología pharmaceutical industry quality sistema de gestión	THE SEMI-QUANTITATIVE DETERMINATION OF MONOBROMED MSc. Yaima López Hernández analytical technique cromatografía capa delgada furvina furvine monobromado monobromed thin layer chromatography técnica analítica validación validation	Experiences of interdisciplinary linkage with Statistics in the training of graduates in Pharmaceutical Sciences. Humberto Nicolás Mora Villegas Statistics estadística formación profesional vocational training

6:00 PM
	Immunogenicity evaluation of the DEC-HER 1 vaccine in the Balbc and C57BL mouse strains Rafael Ojeda dec-her 1; actividad biológica; babl/c; c57bl dec-her 1; biologycal activity; babl/c; c57bl
	Adherence to treatment with metformin in patients with type II diabetes mellitus in area 1 of Cienfuegos Dr.C. Leisy Nieto Reyes adherence to treatment adherencia al tratamiento diabetes mellitus hypoglycemic treatment metformin metformina morisky-green test test morisky-green tratamiento hipoglicemiante

7:00 PM	Adverse drug reactions in the elderly, in the province of Cienfuegos. Dr.C. Leisy Nieto Reyes RAM adulto mayor adverse drug reactions farmavigic older adult reacciones adversas medicamentosas who-art	Colorimetric bioassay to determine the potency of the anti-EGFR monoclonal antibody. Dainelis Torres Rabasa anticuerpo monoclonal bioassay validation monoclonal antibody nimotuzumab validación de bioensayo	Validation of the reverse phase chromatography technique for the identification of the Maelys Miyares Estrada chromatography cromatografía; formulado; péptido. finished product peptide	Design and characterization of a facial serum with beehive products and Aloe vera Laura Amado beehive products cosmetic cosmético design diseño evaluación sensorial facial serum productos de la colmena sensory evaluation serum facial	Establishment of a fermentation process to obtain IFNalfa2b-hr using a chemically defined medium Reinier antibiotics antibióticos chemically defined medium escherichia coli ifnα2b-hr protein medio químicamente definido proteína ifnα2b-hr

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Centro de Análisis del Ciclo de Vida (CADIS)

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