Multicomponent preparation, characterization and in silico analysis of potential inhibitors of Pseudomonas aeruginosa quorum sensing receptor LasR

• Mr. Marcos Rafael Conde González

• English

• molecular docking
• multicomponent reactions
• pseudomonas aeruginosa
• quorum sensing

Pseudomonas aeruginosa is a pathogenic Gram-negative bacterium responsible for several serious infections, being the main cause of pulmonary infections in patients with cystic fibrosis. The expression of the virulence and toxicity factors in the parasite is carried out by a mechanism known as quorum sensing, controlled by various transcription factors, among which is the protein LasR. Blocking this process contributes to prevent damages in animals from the pathogen. Therefore, the synthesis of m...