IDENTIFYING THE INTERACTIONS OF THREE IMMUNOSUPPRESSANTS WITH FKBP12 INTRAMOLECULAR RECEPTOR: A THEORETICAL STUDY

• Sr. Anthuan Ferino Pérez

• English

• dual descriptor
• fkbp12
• molecular docking
• radiolabelling
• rapalogues

Understanding principles of molecular recognition is a challenging problem in contemporary molecular biology and theoretical biochemistry that could be approached with molecular modeling. Peptidyl-prolyl cis-trans isomerase FKBP1A (known as FKBP12) is a member of the immunophilin protein family, which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking and that binds the immunosuppressants rapamycin (sirolimus), everolimus and temsirolimus. An ...