NEW ROUTE TO OBTAIN A FUCOSE DONOR FOR THE SYNTHESIS OF THE LEWIS Y EPITOPE.

• Lic. Yuleidys de Las Mercedes Iglesias Morales

• English

• l-fucose
• synthesis
• α-difucosylation

The glycolipids carrying the antigenic determinant Lewis Y are potential candidates for the development of therapeutic vaccines against different types of cancer. The main problem with Lewis Y synthesis is the α-difucosylation of a lactosamine acceptor with an L-fucose donor. To perform this reaction, one of the best options is the O-(2-O-benzyl-3,4-di-O-acetyl-α/β-L-fucopyranosyl)-trichloroacetoimidate because it provides a high stereoselectivity. However, the reported method to synthesize this...