Trabajos

IN VITRO EVALUATION OF ARYLSUBSTITUTED IMIDAZOLES AS ANTIPROTOZOAL AGENTS AND DOCKING STUDIES ON STEROL 14α-DEMETHYLASE (CYP51) FROM T. CRUZI, L. INFANTUM AND T. BRUCEI.

  • MsC. Julio Rojas Vargas

There is an urgent need to discover and develop new drugs to combat parasitic diseases as Chagas disease (Trypanosoma cruzi), Sleeping sickness (Trypanosoma brucei) and Leishmaniasis (Leishmania ssp). These diseases are considered among the thirteen most unattended diseases worldwide according to the WHO. In the present work, the synthesis of 14 arylsubstituted imidazoles and its molecular docking onto sterol 14α-demethylase (CYP51) was executed. In addition, the compounds, antiprotozoal activit...

Virtual screening and synthesis of novel tetrazole-thiadiazine-2-thionas hybrids

  • Javier Alfonso

Chagas Disease is wide spread through the population in Latin American, affecting around 15 million of people. This illness has been regarded as neglected, since its prevalence is only significant in developing countries. Current therapies are inefficient and a plausible solution is only possible through academic research. The parasitic protozoa responsible for this disease is Trypanosoma cruzi. Trypanothione Reductase (TR) is the main detoxification enzyme of this parasite and it has been ident...

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