CONFORMATIONAL CHARACTERIZATION OF IL-2 MUTEIN BY CIRCULAR DICHROISM AND FLORESCENCE: ITS UTILITY FOR THE INDUSTRY

• Lic. Leina Moro Pérez

• No Presencial
• English

• circular dichroism
• fluorescence
• mil2 and conformational characterization

Circular dichroism and fluorescence spectroscopy are used in the biopharmaceutical industry to study the effects of manufacturing, storage and comparability conditions on protein conformation and stability. These results are often included in the regulatory files. At the Center of Molecular Immunology, a Cuban biotechnology industry, these methodologies have allowed the characterization of the conformational features of products under development, such as mIL2, a mutant of interleukin-2 for the ...