POPULATION PHARMACOKINETIC/PHARMACODYNAMIC OF TWO NOVEL PEGYLATED rHuEPO

• Dr. Gledys Reynaldo Fernández

• English

• hemoglobin
• pegylated erythropoietin
• pharmacometrics
• pkpd
• red blood cells
• reticulocytes

Background and Objectives: Marketed formulations ior®EPOCIM, MIRCERA® and two new branched PEGylated erythropoietin formulations (32kDa-PEG2-rHuEPO and 40kDa-PEG2-rHuEPO) were administered a single dose by intravenous bolus in New Zealand rabbits. The aim of this work was to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model describing in a simultaneous and integrated form the time course of erythropoiesis stimulation after erythropoietin administration. Methods: The PK/PD datase...