``IN VITRO`` BIOLOGICAL AND BIOPHARMACEUTICAL EVALUATION OF THE INCLUSION COMPLEXES OF THE ANTIFUNGAL COMPOUND 2-(2-NITROVINYL)FURAN WITH BETA- CYCLODEXTRIN DERIVATIVES

• Dr. Vivian Ruz

• English

• 2-(2-nitrovinyl)furan
• cytotoxicity
• dissolution
• inclusion complexes
• molecular inclusion complexes
• permeability

Introduction 2-(2-nitrovinyl)furan has antifungal activity, but limited stability. Inclusion complexes with β-CD derivatives are alternatives to solve this problem. This work aimed to evaluate their influence on the drug release, permeability and cytotoxicity, intended for vaginal administration. Methods Freeze-dried complexes (FD ICs) were prepared using a reported method (Ruz et al., 2012). Dissolution studies of pure drug and complexes were carried out in USP dissolution apparatus I. Dissolut...